Peter comes home feeling ill and immediately goes to bed. While Peter is taking photographs of Mary Jane for the school newspaper, one of these new genetically-altered spiders (one which is red and blue) escapes without anyone noticing lands on his hand and hungrily bites him. The lab works on spiders and has even managed to create new species of "super-spiders" through genetic DNA manipulation and combination. Peter's science class takes a field trip excursion to a genetics science laboratory at Columbia University. Norman, the founder, owner and head of weapons contractor of Oscorp Science Industries, appreciates Peter's scientific aptitude and can barely conceal his desire that Peter was his own son. Harry, however, is somewhat jealous of the affection his billionaire scientist father, Professer Norman Virgil Osborn (Willem Dafoe) shows Peter. Peter's only friend is Harold Theopolis "Harry" Osborn (James Franco), who, though rich and good-looking, is similarly an outcast. Her boyfriend, a sports player and the school bully, Eugene "Flash" Thompson (Joe Manganiello) and his buddies bully and pick on him. He has a crush on his next door neighbor, Mariam "Mary" Jane Watson (Kirsten Dunst), who is also one of the few classmates who is nice to him. His parents are dead and he lives with his Uncle Benjamin Franklin "Ben" Parker (Cliff Robertson) and Aunt Mayabella "May" Parker (Rosemary Harris). Peter Benjamin Parker (Tobey Maguire) is a nerdy and shy but intelligent high school senior student at Midtown Secondary College Of Science & Technology in Queens, New York City.
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